Sharif Digital Repository

Herein, we report an efficient one-pot four-component reaction of commercially available 1,3-dicarbonyl compounds, aromatic aldehydes, amines, and nitromethane in the presence of ZnO nanoparticles, which leads to highly substituted pyrroles in moderate to good yields. A mild and efficient tandem process for the synthesis of highly substituted α-pyrones starting from 2-arylacetic acid of high com-mercial availability has been developed. The synthesis is based on the Knoevenagel condensation of 1,3-cyclohexadiones to various β-keto-Esters, followed by lactonization in the presence of 20 mol% ZnO as a nanocatalyst. Moderate to high yields, easily available and less expensive starting materials... 

In the first chapter, high substituted pyrrole derivaitives were synthesized through a one pot four compounent reaction using carbonyl and amin compounds at the presence of magnetic nanoparticles of superparamagnetic ferrospinel NiFe2O4nanoparticles as catalyst.In the second chapter, NiFe2O4magnetic nanoparticles were employed in the Sonogashira reactions using phenyl acetylene as coupling partner with different types of aryle and alkyl halides in water as a green solvent. The results of these reactions were considered comprehensively