Sharif Digital Repository

In this study, the simulation of blood flow through a stenosed coronary artery and a bypass graft are discussed using fluid-structure interaction numerical method. Effects of the geometrical parameters of CABG surgery on hemodynamics have been studied. Investigated hemodynamic variables include shear stress on the vessel wall, the velocity profile in high-risk areas and the pathlines. Lower than 0.5 Pa shear stress on intimal layer of arteries causes the formation of plaque on the wall. Angle of 30 degrees and diameter ratio of bypass to host artery of 1:1 are proposed as the optimum geometry. The distance of the anastomosis from the site of occlusion has no effect on surgery. Also,... 

Cardiovascular diseases are the major cause of death worldwide. Atherosclerosis is one of the major types of cardiovascular diseases in which fibrous and fatty materials, called plaque, build up inside the artery and cause partial or total occlusion of the artery. Intravascular balloon angioplasty with or without stenting is the most common treatment of this disease. In 2010, approximately 954000 stent implantations were performed in the United States. The major issue associated with stenting is reclosure or renarrowing of the transverse section of the artery termed in-stent restenosis (ISR). Unfortunately, nearly one–third of the patients
who receive stent implantation require further...