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Design of Oxidative Stress Nanoparticles for Targeted drug Delivery to the Posterior Segment of the Eye and Breast Cancer
, Ph.D. Dissertation Sharif University of Technology ; Abdekhodaei, Mohammad Jafar (Supervisor) ; Baharvand, Hossein (Supervisor) ; Satarian, Leila ($item.subfieldsMap.e) ; Sadeghi, Hamid ($item.subfieldsMap.e)
Abstract
The oxidation-reduction (redox) responsive micelle system is based on a diselenide-containing triblock copolymer, poly(ε-caprolactone)-bis(diselenide-methoxy poly(ethylene glycol)/poly(ethylene glycol)-folate) [PCL-(SeSe-mPEG/PEG-FA)2]. Resulting in the development of tumor-targeted delivery for hydrophobic anticancer drugs. The diselenide bond, as redox-sensitive linkage, was designed, so it is located at the hydrophilic/hydrophobic hinge to allow complete micelles collapse and efficient drug release, in redox environments. The amphiphilic block copolymers self-assembled into micelles at concentrations above the critical micelle concentration (CMC) in an aqueous environment. Dynamic light...
Scaffold Design and Fabrication for Retinal Tissue Engineering
, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor)
Abstract
The retina, a photosensitive area in the central nervous system, is delicate and intricate. It is susceptible to degenerative disorders such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), Stargardt disease (SD), and glaucoma. These diseases can lead to severe vision loss and ultimately irreversible blindness by causing destruction or dysfunction of different types of retinal cells. Unfortunately, there are no proven treatment strategies to cure or reverse these degenerative disorders. However, cell transplantation therapies may be an alternative to replace distorted cells and improve an individual's vision. Recent clinical outcomes show that transplanted cells in the...
A Bio-Inspired Modeling of the Retina
, M.Sc. Thesis Sharif University of Technology ; Vosoughi Vahdat, Bijan (Supervisor)
Abstract
The retina is a light-sensitive layer of tissue at the back of the eyeball wall and is the initial stage of the brain's visual processing stages. This tissue contains more than 60 types of neurons placed in different neuronal layers. All the visual information received from the surrounding environment passes the retina and is encoded into neural signals. Therefore, studying the retina's functionality and bio-inspired modeling of its neurons and their connections are essential in recognizing visual dysfunctions caused by problems in the retina. Also, this modeling can help researchers in proposing solutions for building retinal prosthetics and, in general, performing simulations in the...