Sharif Digital Repository

Some widely used drugs such as paclitaxel (PTX) are poorly water soluble. The clinical use of PTX with solubilizer causes side effects. These problems limited its application in treatments. In this work has been studied the effect of β-CD-g-PG (HPCD) hybrid nanomaterials, conjugated PG branches onto β-CD core, on the water solubility of PTX. First HPCD has been synthesized. Then the inclusion complex of PTX with HPCD was prepared. The inclusion complex efficiency for PTX:HPCD complex in 1:25 mole ratio was 87%. Then solubility of PTX with HPCD in water has been determined, showing Ap type phase solubility diagram. Then stability constants were calculated. The first order and second order... 

Paclitaxel is using as a drug against breast and ovary cancers. Although paclitaxel has high biologic activity, it has very poor solubility in water the same as some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites.
Beta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project, by adding polymeric polyglycerol branches on Beta-Cyclodextrin, a polymeric nanostructure has been developed to enhance water solubility in comparison with pure Beta-Cyclodextrin.
Study on producing... 

Flagella is the organelle involved in motility of Salmonella and plays an important role in colonization of Salmonella. Flagellins is the structural subunits of flagellar filament that is known as an adjuvant. Recombinant production of flagellin of S. enteritidis is advantageous due to the removal of pathogenic microorganism from the production process and improved process safety. E.coli is an appropriate host for the expression of recombinant proteins. However, its major obstacle is the formation of inclusion bodies. Inclusion bodies are aggregated inactive proteins and the recovery of proteins in the active form from these aggregates usually has a low yield. Therefore, the objective of our... 

Paclitaxel is used as a drug against breast and ovarian cancers. Although paclitaxel has high biologic activity, it has very pour solubility in water like some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites. eta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project by adding polymeric polyacrylamide branches on beta-Cyclodextrin, polymeric nano structure has been developed to enhance water solubility in comparison with pure beta-Cyclodextrin. Study on producing polymeric nano... 

Nickel-titanium nanoparticles showing shape memory properties at nanoscale, have recently attracted much attention as nanoactuators in the field of nano-electro-mechanical systems. So, spark discharge method was utilized in this study for synthesis of NiTi nanoparticles. First step was to design and build a suitable set-up for synthesis of nanoparticles with high qualities at a high production rate. Nextly, NiTi nanoparticles were synthesized from prealloyed electrodes at a positive pressure and were characterized by the EDS, XRD, SEM and DSC methods. The obtained product was as agglomerated nanoparticles having sizes of around 40nm with primary particle size of <10nm. Chemical composition... 

Due to their low volatility, negligible flammability, and high regeneration capacity, ionic liquids have attracted a lot of attention in chemical and process engineering fields. Regarding the limited access to the laboratory facilities, developing theoretical methods such as equations of state is important in this research field. Thus, data for density and viscosity of pure ionic liquids and vapor pressure data for binary mixtures of ionic liquids and acidic gas have been collected and validated from the IL Thermo website for 42 ionic liquids. By consideration of theoretical studies and comparison of the performance of different cubic equations of state in predicting the aforementioned... 

The purpose of this research is to model transport and separation of single and gas mixtures through pore network modeling in dense membranes. In the first part of the project, the mass transfer and governing mechanisms of transport are investigated. In the second part of the project, simulation of membrane pore network in 3D of Cartesian coordinate is done. In the third part of the project permeability of single gas and ideal selectivity of binary gases for an actual membrane by desired mechanism are calculated. Then the results of pore network modeling were compare with the results from molecular dynamic simulation for single gas in polyurethane membrane with reasonable agreement. In this... 

Efforts to identify, predict, and resolve problems linked to asphaltenes and flow assurance have resulted in the development of numerous laboratory and modelling techniques. However, there has been little research on the molecular structure of asphaltenes and how it relates to solubility, stability, aggregation, and deposition behavior. Not only was a thorough structural analysis of asphaltene extracted from three samples of light, medium, and heavy oil performed in this study, but medium oil asphaltene was also fractionated into three sub-fractions based on solubility, with minimum, medium, and maximum solubility, and each subfraction was subjected to a structural analysis. All asphaltene...