Sharif Digital Repository

The use of nanocarriers has been recently considered for targeted drug delivery. In the targeted drug delivery systems, drug is directed to the target tissue and its adverse effects are reduced on the healthy tissues. Graphene oxide and hollow mesoporous carbon nanospheres are two types of the most interesting carbon-based nanocarriers because of their unique properties. Aim of the thesis has been the synthesis of the nanocarriers based-on graphene oxide and hollow mesoporous carbon nanospheres and their surface modifications by magnetic polyamidoamine dendrimer and oxygen-rich polymers such as poly(epichlorohydrin) and hyperbranched polyglycerol. These modifications result in higher... 

Theranostic liposomes have recently found a broad range of applications in nanomedicine due to stability, the high solubility of biomacromolecules, bioavailability, efficacy, and low adverse effects. However, the limitations of liposomes concerning the short systemic circulation in the body, limited controllability of the release rate, and the inability of in vivo imaging remain challenging. Herein, the development of novel hybrid ultrasound-activated piezoelectric nanoparticles based on a hybrid liposome nanocarrier composed of poly(vinylidene fluoride‐trifluoroethylene), graphene quantum dots (GQDs), and Silibinin (a hydrophobic drug) is presented. The hybrid nanoparticles are an... 

The aim of this research is to develop a smart mesoporous bioactive glass-based carrier for targeted drug delivery to cancer cells, particularly bone cancer cells. To achieve this, mesoporous bioactive glass nanoparticles were first synthesized, followed by surface modification with amine groups. To prevent premature drug release before reaching the target tissue and to introduce pH sensitivity, the nanoparticle pores were coated with oxidized hyaluronic acid via Schiff-base bonding with the amine groups on the surface. The use of hyaluronic acid facilitates active targeting of CD44 receptors, which are overexpressed on the surface of cancer cells compared to healthy cells. This process...