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taxol
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Characterization of Essential Oil Components of Green and Black Cardamoms Using GC-MS Combined with Chemometric Resolution Techniques & Quantification of Two Types of Taxus Using Fast Liquid Chromatography Combined with MCR
,
M.Sc. Thesis
Sharif University of Technology
;
Jalali Heravi, Mehdi
(Supervisor)
Abstract
Progress in analysis of multicomponent mixtures and processes focused on the interpretation of the multivariate responses, rely on the combination of sophisticated instrumental techniques and suitable chemometric methods. Among the present chemometric method, curve resolution techniques have a wide application in the analysis of multicomponent mixtures and processes. Chemometric resolution techniques are used in the present work. At the first, Essential oil of green and black cardamoms was extracted by hydrodistillation and was analyzed by gas chromatography–mass spectrometry (GC-MS). Due to the fact that the essential oils are complex mixtures, strong overlap is observed between the peaks....
Synthesis of Molecularly Imprinted Nano-porous Polymer for the Enrichment of Taxol as Anti-Cancer Agent
, M.Sc. Thesis Sharif University of Technology ; Abdekhodaie, Mohammad Jafar (Supervisor) ; Nematollahzadeh, Ali (Co-Advisor) ; Musavi, Abbas (Co-Advisor)
Abstract
In the present research, first, a series of molecular dynamics (MD) simulations of pre-polymerization mixtures for taxol (template) imprinted polymers was performed to select an appropriate monomer and its intermolecular bonds with the template. Finally, after synthesis, performance and morphological evaluation of taxol imprinted polymer were presented. In the molecular modeling step, a virtual library of functional monomers was created containing eleven frequently used monomers. The MD simulations were first conducted to select the optimum monomer from the virtual library using acetonitrile as porogen. Methacrylic acid among the studied functional monomers was found to possess stronger...