Sharif Digital Repository

In the first chapter, three efficient synthesis of novel polyheterocyclic indole and thiochromone-annulated thiopyranocoumarin derivatives are achieved via domino Knoevenagel hetero Diels–Alder reaction of O-acrylated and O-propargylated salicylaldehyde derivatives with indolin-2-thiones and 4-hydroxy dithiocoumarin. The domino Knoevenagel-hetero-Diels–Alder reactions are very efficient process that allows the formation of two or more rings at once, avoiding sequential chemical transformations. The products are formed in good-to-excellent yields with high regio- and stereoselectivity. The major advantage of this reaction is the ease of the work-up during which the products can be isolated...