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thiazolidindione
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Synthesis of Dithiocarbamate Derivatives and Their Applications to Prepare Heterocyclic Compounds
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Reza (Supervisor)
Abstract
Sulfur containing compounds are known as the most applicable group of organic compounds. Due to their medicinal and biological applications, dithiocarbamates are the most considerable among the many sulfur containing compounds. There are many procedures reported to synthesize these compounds as synthetic intermediates instead of thiophosgen and isothiocyanates. The reaction of amine and carbon disulfide is reported as the best and least hazardous way to synthesize this functional group. In this project heterocyclic compounds such as thiazoles, thiazolidine-2-thione, and 2-(alkylthio)thiazol-4(5H)-one derivatives were synthesized from the reaction of prepared dithiocarbamates with in situ...
The First Category of Organic Cation-Cation Cluster, A DFT Study and Synthesis of Thiazolidinedione, Rhodanine and S-Transalkylation of Dithiocarbamates
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Reza (Supervisor) ; Fattahi, Alireza (Supervisor)
Abstract
In this study, using the B3LYP/6-3111++g(d,p) computational level, we have explored the possibility of formation of some organic and bioorganic cation-cation clusters (CCC) in the absence of any anionic stabilizing species. Furthermore, we have shown the existence of a barrier energy for exothermic dissociation of these clusters. Herein, we have selected some biomolecules such as the chloroquine (CQ) antimalarial drug . The selected molecules possess the basic sites and can function as both hydrogen bond donors and acceptors. Also, a facile and direct synthetic route toward the rhodanine derivatives and thiazolidine-2,4-diones via a three-component coupling of carbon disulfide, primary...