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tizanidine
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Colorimetric Determination of Tizanidine and Mercury (II) Based on Aggregation and Anti-aggregation of Gold Nanoparticles
, M.Sc. Thesis Sharif University of Technology ; Hormozi Nezhad, Mohammad Reza (Supervisor)
Abstract
In the first section of this research, we have developed a simple and rapid colorimetric method for determination of tizanidine using citrate capped gold nanoparticles. Under optimal conditions, the AuNPs easily aggregate upon addition of tizanidine and the solution color changes from red to gray. This color change was followed using a UV-Vis spectrophotometer. The detection limit was calculated to be 0.48 µM. The method was successfully applied for determination of tizanidine in Spalex© tablets. In the last section, the anti-aggregation effect of Hg(II) on the tizanidine-AuNPs system was utilized with the aim of developing a colorimetric method for detection of Hg(II). Addition of...
Electrochemical Sensors Based on Electrodes Modified with Composites of Carbon Nanostructures and Polypyrrole; Application to Electrochemical Investigations and Determination of Nifedipine and Tizanidine
, M.Sc. Thesis Sharif University of Technology ; Shahrokhian, Saeed (Supervisor)
Abstract
In the first part, the electropolymerization of pyrrole was performed in the presence of Titan Yellow (TY) as a dopant anion on the surface of the electrode precoated with CNTs. The modified electrode was used to study the voltammetric response of tizanidine (TIZ). A remarkable increase was observed in the anodic peak current of TIZ on the surface of the modified electrode relative to the bare GCE. The surface morphology PPY/CNT/GCE was thoroughly characterized by scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques. Under the optimized analysis conditions, the modified electrode showed two linear dynamic ranges of 0.01 - 1 μM and 1-10 μM with a detection limit of 3 nM...