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Synthesis and Biological Evaluation of Superparamagnetic Iron Oxide Nanoparticles as Contrast Agents for Bioimaging Applications
,
M.Sc. Thesis
Sharif University of Technology
;
Maddah Hosseini, Hamid
(Supervisor)
;
Oghabian, Mohammad Ali
(Supervisor)
Abstract
A biocompatible ferrofluid containing ?Fe?_3 O_4 nanoparticles was produced using co precipitation of ?FeCl?_2.?4H?_(2 )O and ?FeCl?_3 ?6H?_2 O under ultrasonic irradiation power with NaOH being the alkaline. Two variables studied in this research were concentration and molecular weight of PEG, as the coating agent. The impact of these variables were carefully monitored on shape, size distribution and magnetic behavior of nanoparticles through SEM, DLS, XRD and VSM characterization techniques. Moreover, MRI relaxation times,T_1and T_2, were calculated using synthesized nanoparticles as contrast agents. Accordingly these nanoparticles were biologically evaluated by MTT assay. Results...