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Modeling Propagation of Cardiac Action Potential at Cellular Level

Farahani, Mojtaba | 2009

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 39710 (05)
  4. University: Sharif University of Technology
  5. Department: Electrical Engineering
  6. Advisor(s): Jahed, Mehran
  7. Abstract:
  8. Heartbeat is the result of contractions of over 10 billion cardiac cells. These cells’ cytoplasms are connected to each other by gap junctions which are arrays of intercellular protein channels. Thus action potential can propagate from one cell to another and cause its contraction. In core-conductor model, one-dimensional microscopic representation of cardiac tissue, cells are attached to each other to form a ladder network. The parallel elements are connected to each other by series resistors which represent gap junctions. These resistors are nearly always considered as static elements. In this thesis I have investigated the effects of incorporating the dynamicity of gap junction resistors on the action potential velocity in normal and ischemic cardiac tissue. I conclude that the effect is elated in case of increased resting gap junction resistor, such that the propagation velocity is decreased by 0.83% for R=2MΩ and by 16.83% for R=100MΩ. These values are reduced in ischemic tissue. For example the reduction is only 0.62% for R=10MΩ. From here I conclude that the magnitude of the effect of gap junction dynamicity is depressed in high propagation velocity and reduced action potential amplitude. In normal tissue the cells are electrically well coupled and this effect is insignificant, so by ignoring it we can reduce the simulation time by a factor of five
  9. Keywords:
  10. Heart ; Action Potential ; Cellular Modeling ; Cardiac Ischemia ; Gap Junction ; Core Conductor Model

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