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Electrochemical Determination of Piroxicam at thin Carbon
Nanoparticle Composite And Investigation of the Electrochemical Behavior and Synthesis of Catechols in the Presence of Mercapto Methyl Tetrazol as a Nucleophile

Jokar, Effat | 2009

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 39784 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Shahrokhian, Saeed
  7. Abstract:
  8. The electrochemical oxidation behavior of the anti-inflammatory drug piroxicam was investigated. A carbon nanoparticle (CNP)-chitosan (CS) film-coated graphite electrode (PGE) was fabricated and the electrochemical behaviors of piroxicam on its surface was investigated by the means of cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS). In comparison to the bare PGE, at the surface of the CNP-CS film modified electrode, the oxidation peak current of piroxicam increased significantly and the peak potential shifted negatively. Consequently, a simple and sensitive electroanalytical method was developed for the determination of piroxicam. The oxidation peak current was proportional to the concentration of piroxicam from 5.0×10-8 – 5.0×10-5 for 120s accumulation at open circuit. The analytical applicability of the prepared modified electrode is evaluated by analyzing piroxicam tablets and in human blood serum sample and satisfactory results are obtained. Electrosynthesis is one of the prime principles of green chemistry is to develop an alternative reaction medium, which is the basis for the development of many cleaner chemical technologies and electrochemical synthesis in water. Catechols are a promising group of compounds worthwhile for further investigation, which may lead to the discovery of selective acting, biodegradable agrochemicals having high human, animal and plant compatibility. Electrooxidation of catechol and 4-methyl catechol in the presence of 5-mercapto-1-methy-l tetrazole as a nucleophile in aqueous buffered solutions was studied by cyclic voltammetry and controlled-potential coulometry. The mechanism of electrochemical reaction is confirmed by cyclic voltammetry in various times of controlled-potential coulometry. The voltammetric and spectrophotometric foundations indicate that a 1,4 Michael addition of tetrazole from its thiol moiety to the electrochemically derived o-quinone is occurred. The electrochemical synthesis of Michael addition product has been successfully accomplished by controlledpotential coulometry in a divided H-type cell and the reaction product was characterized by spectrophotometric, 1H and 13C NMR, elemental analysis and mass spectrometric methods
  9. Keywords:
  10. Electrosynthesis ; Catechol ; Carbon Nanoparticles ; Chitosan ; Cyclic Voltammetry ; Mercaptomethyl Tetrazole ; Piroxicam ; Modified Electrodes

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