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Some Studies on Conjugation of Nanoparticles Fe3O4 (Fe2O3) to PEG for Drug Delivery Systems

Mohseni Ahooyi, Taha | 2010

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 40528 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Vossoughi, Manouchehr; Yaghmaei, Soheila
  7. Abstract:
  8. The main strategy for treating solid cancers is based on the very early diagnosis of a malignant tumor, and in general the smaller the tumor, the greater the likelihood of successful treatment. Magnetic Resonance Imaging (MRI), based on the nuclear magnetic resonance phenomenon, provides the possibility of detecting early malignant tumors with the assistance of appropriate contrast agents. Hence, researchers continue to develop novel magnetic materials to achieve this aim. Superparamagnetic nanoparticles have become the focus of these studies because their superparamagnetic, biocompatible and hydrophilic properties would be revealed after modifying the particle surface by suitable surfactants. Considerable research in this area has provided valuable insights; however, suitable magnetic materials that can fulfill all the requirements of MRI
    application are still under investigation. Surface modification of superparamagnetic nanoparticles towards their use as MRI contrast agents has been the topic for many researchers, but implementation into fully functional in vivo procedures still remains as a challenging task. In the present study, high quality monocrystalline iron oxid nanoparticles have been synthesised and surface-modified with (PEG). Furthermore, the coating procedure was optimised to prevent aggregation among the nanoparticles. PEG-coated nanostructures were characterised by using X-ray Diffraction Spectroscopy (XRD), Fourier Transformer Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS). Consequently, mono-dispersed coated nanoparticles were obtained with an approximate hydrodynamic diameter of 6 nm. The resulting coated nanoparticles exhibited the nanostructures with an excellent colloidal stability in physiological environment even at high salt concentration. The resistance to non-specific protein adsorption was investigated in an in vitro model. PEG-coated nanoparticles displayed low non-specific adsorption. However, the free carboxyl groups could be activated to covalently immobilize proteins.
  9. Keywords:
  10. Polyethylen Glycol (PEG) ; Co-Precipitation ; Crystallization ; Drug Delivery ; Magnetic Nanodot ; Sodium Lauryl Sulfate

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