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Drug Retard Release Membrane by Supercritical Systems

Shafiee, Alireza | 2010

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 40901 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Goodarznia, Iraj; Soltanieh, Mohammad
  7. Abstract:
  8. The purpose of the present project is to construct and improve the quality of an absorbable membrane using a supercritical process and study the effects of the operative parameters. Today, usage of biodegradable polymers is intensively increasing and these kinds of polymers are used as drug delivery carrier and tissue engineering medium. A biodegradable membrane is suitable for this goal. In this study Poly Ethylene Glycol (PEG) is used as the biodegradable polymer. Gas anti-solvent (GAS) method was applied for the production of the membrane. The used anti-solvent was Supercritical Carbon Dioxide. In order to study the effects of the operative parameters on the structure of the produced membrane, length and width size of particles and increasing of the length of particles versus the diameter of particles which make the membrane in purpose of improving the quality of membrane, was considered as a symbol of the membrane structure. Operative parameters consist of the final pressure, temperature, primitive solution concentration and the slope of increasing pressure from primitive pressure to final pressure that result shows that decreasing final pressure and slope of increasing pressure and increasing concentration and operative temperature, length and diameter of particles increase that the influence of decreasing slope of increasing pressure on increasing length of particles is more than increasing diameter of particles and it can be predicted that by optimum operative situations, particles with length of 133 μm and diameter of 36 μm are produced. To decrease the number of needed trials Taguchi Method for experiment design was used.

  9. Keywords:
  10. Supercritical Antisolvent ; Membranes ; Nucleation ; Taguchi Method ; Biodegradable Polymer

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