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Synthesis and Characterization of Superparamagnetic Iron Oxide Nanoparticles Via Microemulsion (Reverse Micelle) Method as MRI Contrast Agents

Pelaschi, Mohammad Ali | 2010

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 41637 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Madah Hosseini, Hamid Reza
  7. Abstract:
  8. Iron oxide nanoparticles were synthesized using microemulsion technique as MRI contrast agents. Utilization of nanoparticles for biological applications and in this case as MRI contrast agents needs particles to be of small size and also narrow size distribution. For this aim, the effect of several parameters on size and size distribution has been studied. These parameters include water/surfactant ratio, precursor’s concentration and amount of polymer employed to improve nanoparticles colloidal stability. XRD, FE-SEM and TEM results reveal that the synthesized nanoparticles had small size (about 10 nm iron oxide core and 20 nm overall diameter) and possessed narrow size distribution (15-21 nm). It has been confirmed that the increase in water/surfactant ratio, precursor’s concentration or applied polymer amount will result in bigger particles. Surface of produced nanoparticles was investigated using FRIT, TGA and zeta potential methods. The results indicate that the toxic CTAB has been removed from nanoparticles after several steps of washing by distilled water and ethanol and also a layer of polymer (PEG) is deposited on nanoparticles. To enhance the biocompatibility of nanoparticles, it is necessary to remove surrounding toxic CTAB and substituting a biocompatible polymer layer on nanoparticles. Finally nanoparticles have been investigated as a potential MRI contrast agents. VSM, DLS and T1/T2 analyses were used for this purpose. VSM results imply that the synthesized nanoparticles exhibit superparamagnetic behavior (HC about 2 Oe) and have the magnetic saturation of 34-46 emu/gr (10-22 nm iron oxide core diameter). T1/T2 analyses revealed the relaxation time of nanoparticles as well as their capability to act as MRI contrast agents. T1/T2 and other studied Results signify that the synthesized nanoparticles can be proper candidates for MRI contrast agents.
  9. Keywords:
  10. Iron Oxide Nanoparticles ; Polymer Coating ; Microemulsion ; Superparamagnetic Nanoparticles ; Magnetic Resonance Imagin (MRI)Contrast Agent

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