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Simulation of Red Blood Cell Passing Through Microvessels

Hasanian, Mostafa | 2011

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 41433 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Ahmadiyan, Mohammad Taghi; Firoozbakhsh, Keikhosrow
  7. Abstract:
  8. Red Blood Cells (RBCs) are the main cells in human blood with a main role in mechanical properties of blood as a fluid. Several methods are developed to simulate the behavior of RBCs motion and deformation in micro-capillaries. Since in microscopic scales, using discrete models are more preferred than continuum methods, moving particle semi-implicit method (MPS) which is one of the recent innovative particle based methods, can simulate micro-fluidic flows based on Navier-Stocks equations. Although by the recent developments MPS method has turned into a considerable tool for modeling blood flow in micro-scales, but still some problems, such as commitment to use small time steps, restrict the method for large models and long time simulations. In this dissertation a new modified semi-implicit algorithm is developed and implemented on RBC motion in microvessles in order to reduce the calculation time more than the factor of twenty, while the error of position and velocity remains constant. A two-dimensional parallel plate fluid flow is simulated based on proposed method and the effect of calculation time decrement is evaluated. Findings compared with previous studies with the same results, indicate the reduction of 90 percent in simulation time. In order to understand the behavior and function of living red blood cells, this significant developed method is applied to RBC interaction within micro-capillaries and constricted zones. Results show that this new MPS algorithm can be used for further studies to achieve more outcomes with higher accuracy
  9. Keywords:
  10. Simulation ; Lagrangian Method ; Red Blood Cell ; Moving Particle Semi Implicit ; Mechanical Properties ; Microvessel

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