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Biopolymers Mediated Green Synthesis of Silver Nanoparticles With Definite Shape and Their Biomedical Activity Investigation

Soleyman, Rouhollah | 2012

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 42914 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Pourjavadi, Ali
  7. Abstract:
  8. Silver nanoparticles (Ag-NPs) are promising agents in bionanotechnology, because of their unique activity against unfavorable processes in bioscience such as undesirable microbial growth, angiogenesis in tumors and etc. Ag-NPs have been widely used in wound dressing; wound healing, water treatment filters, inks, sensors, catalysts, cosmetics, orthopaedics, surgical instruments and vascular prosthesis. Ever-increasing applications of Ag-NPs in biomedical field are due to the anti-bacterial, anti-fungal, anti-viral, anti-platelet, anti-proliferative, anti-inflammatory (apoptosis detection) and anti-angiogenesis properties (cancer therapy). In the current research, we synthesized Ag-NPs in aqueous solution at room temperature based on the main principles of the green synthesis, using sunlight-UV as facile nontoxic reducing agent. Gelatin, kappa carrageenan (κC) or salep, as a fully biocompatible capping/shaping agent, brought about stabilization of the silver nano-sphere (4.1 nm), nano-cube (5.2 nm), nano-wedge (100 × 500 nm) and nano-rod (150 × 450 nm) in solution. Then, microbicidal activity of Ag-NPs against Escherichia coli Gram-negative bacteria (MIC = 2-15 μg/mL), Staphylococcus aureus Gram-positive bacteria (MIC = 5-15 μg/mL) and Candida albicans fungi (MIC = 2-12 μg/mL)) were evaluated and showed potent and acceptable results which confirm the theory of Ag-NP shape relation with antibacterial activity.

  9. Keywords:
  10. Silver Nanoparticles ; Saleb ; Gelatin ; Kappa-Carrageenan ; Biomedical Activity

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