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Phenomenological Study of Granulation by Investigating the Effects of Operating Parameters on Granule Properties

Ranjbarian, Sima | 2013

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 44674 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Farhadi, Fathollah
  7. Abstract:
  8. The present thesis has provided more fundamental understanding of granulation rate processes (such as coalescence, attrition and breakage) by investigating the effects of operating parameters on product properties. The studied process was wet granulation carried out in two high shear mixer granulators. Granulation duration, binder mass and impeller speed were considered as operating parameters and granule size distribution (measured by sieving) and granule binder distribution (measured by thermogravimetery method) were regarded as product properties. Experiments were conducted in two analogous cylindrical and conical high shear granulators. The obtained experimental and theoretical results included valuable information regarding granulator design, the method of stable granule producing and the correct techniques of measuring granule properties. Furthermore, the results represented the qualitative and quantitative changes of granule properties in accordance with the variations of operating parameters and elucidated these observations according to the competition of granulation rate processes. Consequently, the results have been led to an innovative method of dominant rate process detemination, an inventive breakage regime map and a novel relationship between dimensionless granule mean diameter and two essential dimensionless numbers (maximum pore saturation and Stokes deformation number). The present thesis has related macro-scale changes of granule properties with meso-scale variations in the process and provided the opportunity of process prediction and generalization, qualitatively
  9. Keywords:
  10. Wet Granulation ; High Shear Mixer Granulator ; Impeller Speed ; Binder Distribution ; Response Surface Methodology

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