Fluids Flow Simulation in the Cell Influenced the Focal Adhesions

Nikmaneshi, Mohammad Reza | 2013

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 44759 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Firoozabadi, Bahar; saidi, Mohammad said
  7. Abstract:
  8. In the present thesis, intracellular fluid flows have investigated for study cell motions. It is due to firmly relation between the cell motion and these flows. Generally, the cell firstly adheres to a surface, then, moves forward with the effects of the internal fluid flows. In this study, the cell structure is invided to two general parts; the front part of the cell and the cell body. The front part of the cell plays a essential roles in the cell motion, however, the cell body is considered as a extra cargo that is carried by the front of the cell. Therefor, in the present modellings, the front part is only considered. Here, using four different models for the front part of the cell, many aspects of the cell movment and the factors that affect on it, have investigated. First model; a two-dimensional and one-phase model involved the F-actin flow for a strip of the lamellipodium part of a lowly velocity cell such as epithelail, and aimed mechanical interactions between the lamellipodial actin network, adhesion and membrane. Indeed, the curvature of the cell membrane due to the focal adhesion existence is considered. Second model; a two-dimensional and one-phase continuum model involved just the F-actin flow for a strip of the part of a lowly velocity epithelail cell, and the purpose is investigation of the arclike boundary of the lamellipodium and lamellum. This boundary is illustrated by the stress distribution and the yield stress for the F-actin network. Third model; a two-dimensional and one-phase continuum model of the flat and fan-like lamellipodia region of the keratocyte cell. In this work, the directional influenced of the myosin motor proteins on the F-actin flow is considered. Final model that is a next pattern of the third model; a continuum two-phase model for the F-actin and cytosolic flow investigation. Indeed, in this model, the effects of the interphase forces on the flow patterns are assessed, and the results are compared to the single phase models
  9. Keywords:
  10. Cell Membrane ; Actin Network ; Myosin Motor Proteins ; Focal Adhesion ; Polymerization ; Lamellipodium ; Lamellum

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