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Development and Application of Carbon Nanomaterials-based Polymer Modified Electrodes for Electrochemical Determination of Pharmaceutical Compounds

Kamalzadeh, Zahra | 2013

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 44819 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Shahrokhian, Saeed
  7. Abstract:
  8. In this thesis, in the first part, a promising electrochemical sensor was developed based on a layer by layer process by electropolymerization of pyrrole in the presence of new coccine (NC) as dopant anion on the surface of the CNTs pre-coated glassy carbon electrode (GCE). The modified electrode was used as a new and sensitive electrochemical sensor for voltammetric determination of sumatriptan (SUM). The results showed a remarkable increase in the anodic peak current of SUM in comparison to the bare GCE. In the second part, the electropolymerization of pyrrole was performed in the presence of Nitrazine Yellow (NY) as a dopant anion on the surface of the electrode precoated with CNTs. The modified electrode was used to study the voltammetric response of naltrexone (NTX). A remarkable increase was observed in the anodic peak current of NTX on the surface of the modified electrode relative to the bare GCE. In the third part, the electropolymerization of pyrrole was performed on the surface of the electrode precoated with a thin film of carbon nanomaterial. Morphology, thickness, stability and loading of the electrochemically generated PPY film were significantly influenced by the structure and morphology of the sub-layer of carbon nanomaterial. The electrochemical behavior of atorvastatin (ATOR) was investigated on the surface of the modified electrode. Under the optimized conditions, a significant increase was observed in the anodic peak current of ATOR on the surface of the CNTs/PPY modified electrode relative to other modified electrodes and bare GCE. Also there was a negative shift in the oxidation peak potential, in comparison to the bare GCE. In the fourth part, the electrooxidation of clozapine (CLZ) was studied on the surface of GCE modified with a thin film of CNTs/NC doped PPY. The pH of the supporting electrolyte (D), drop size of the cast CNTs suspension (E) and accumulation time of CLZ on the surface of modified electrode (F) was considered as effective experimental factors and the oxidation peak current of CLZ was selected as the response. The optimum values of factors were obtained by using factorial-based response-surface methodology. Under the optimized conditions, a significant increase was observed in the anodic peak current of CLZ on the surface of the modified electrode relative to the bare GCE
  9. Keywords:
  10. Polypyrrole ; Composite ; Carbon Nanotubes ; Carbon Nanomaterials ; Modified Electrodes ; Experimental Design ; Cyclic Voltammetry

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