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Straightforward and highly efficient catalyst-free one-pot synthesis of dithiocarbamates under solvent-free conditions

Azizi, N. (Najmodin) ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1021/ol0620141
  3. Abstract:
  4. A highly efficient and simple synthesis of dithiocarbamates is possible based on the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochemical industries
  5. Keywords:
  6. Thiocarbamic acid derivative ; Catalysis ; Chemical structure ; Synthesis
  7. Source: Organic Letters ; Volume 8, Issue 23, 9 November 2006, Pages 5275-5277
  8. URL: http://www.organic-chemistry.org/abstracts/lit1/483.shtm