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Highly efficient one-pot three-component Mannich reaction in water catalyzed by heteropoly acids [electronic resource]

Azizi, N. (Najmodin) ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1021/ol060498v
  3. Abstract:
  4. Heteropoly acids efficiently catalyzed the one-pot, three-component Mannich reaction of ketones with aromatic aldehydes and different amines in water at ambient temperature and afforded the corresponding β-amino carbonyl compounds in good to excellent yields and with moderate diastereoselectivity. This method provides a novel and improved modification of the three-component Mannich reaction in terms of mild reaction conditions and clean reaction profiles, using very a small quantity of catalyst and a simple workup procedure
  5. Keywords:
  7. Source: Org. Lett ; 2006, 8, 2079-2082
  8. URL: http://pubs.acs.org/doi/abs/10.1021/ol060498v