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Indirect Sensitization of Doped Titanium Dioxide Nanoparticles for Photodynamic Therapy Application

Hassanzadeh Azami, Roozbeh | 2013

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 45714 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Maddah Hosseini, Hamid Reza; Mohammadi, Mohammad Reza
  7. Abstract:
  8. Photodynamic therapy that has developed over last century, now has become more widely used medical tool for the treatment of various diseases such as cancer. This technique involves delivery of photosensitizing drugs, irradiation of light and motivation of drugs. The limitation of light penetration in body tissue, may resolve by application of upconversion nanoparticles. Upconverting nanoparticles could help treatment of cancer tumors in deep or critical points of body by converting high penetrating Near-Infrared emissions to higher energy visible emissions.In this research Er3+-Yb3+ Co-doped titanium dioxide upconversion nanoparticles prepared by Sol-gel method. The phase structure and optical properties of nanoparticles characterized by using photoluminescence spectroscopy, UV-Visible spectroscopy, X-ray diffraction, Raman and FT-IR spectroscopy. Appearance of Er2Ti2O7 and Yb2Ti2O7 pyrochlore phase in XRD diffraction pattern suggests that the dopants fully integrated in matrix structure. Presence of rare earth elements peaks in UV-Visible spectra also confirmed this point. Upconversion emissions were observed after excitation of nanoparticles with 980 nm Near-Infrared laser diode. Photoluminescence spectroscopy admit presence of green 520-570nm and red 640-690 nm and blue 408nm emissions
  9. Keywords:
  10. Sol-Gel Method ; Titanium Dioxide Nanoparticles ; Rare Earth Element ; Photodynamic Therapy ; Upconversion Nanoparticles

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