The Reaction of α-Haloketones with Dithiocarbamate Derivatives for the Synthesis of 2-Alkylthiothiazole Heterocyclic Compounds

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Hasani, Leila | 2014

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 46373 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Saeedi, Mohammad Reza; Ziyaei Halimehjani, Azim
Abstract:
The reaction of α-haloketones with a variety of dithiocarbamate derivatives for the synthesis of various 2-alkylthiothiazole heterocyclic compounds was investigated in this thesis. To this end, different dithiocarbamates were initially synthesized through the reaction of amines, carbon disulfide and various alkyl halides; then, these dithiocarbamates were reacted with α-bromoketones (bromoacetophenone and chloroacetone) resulting in the formation of range of 2-alkyl thiothiazoles. To optimize the reaction conditions, ethanol and water were tested as solvents in the presence of ZrCl4 as catalyst. According to the data obtained, ethanol was selected as the optimum solvent using ZrCl4 as catalyst. Identification and characterization of all products were done using 1HNMR، 13CNMR and CHNS analyses
Keywords:
Dithiocarbamate ; Heterocylic Compounds ; 2-Alkylthiothiazol ; Alpha-Haloketone

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