Synthesis of Bromonitroalkenes and their Applications as Electrophile in the Reaction with Indoles

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Rostami Rad, Marzieh | 2014

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 46607 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Mahmoodi Hashemi, Mohammad; Ziyaei Halimehjani, Azim
Abstract:
In this work Nitroolefins were made by aromatic aldehydes consisting of electron withdrawing and electron donor groups. Afterward β-Bromo-β-nitrostyrenes were produced from interaction between nitroolefins and brom, at suitable temperature. After providing ingredients, micheal reaction (Friedel-crafts Pseudo-alkylation) between nitroolefins and various nucleophiles such as indoles was investigated. Finally desired micheal products were achived with high efficiency
Keywords:
Indole Synthesis ; Aromatic Aldehydes ; Nitroalkene ; Beta-Bromo-Beta-Nitrostyrene

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