Synthesis of Graphene Quantum Dots for Biomedical Application

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TaghaviLarijani, Hanieh Sadat | 2014

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Type of Document: M.Sc. Thesis
Language: English
Document No: 46694 (57)
University: Sharif University of Technology, International Campus, Kish Island
Department: Science and Engineering
Advisor(s): Sadrnezhaad, KHatiboleslam; Ahhadiaan, Mohammad Mehdi
Abstract:
Graphene quantum dots (GQDs) as a sort of carbon-based nanomaterials are applied in a multitude of exciting areas. They are effective fluorescent probe for many potential biological and medical applications. In comparison to conventional organic fluorescent probes (organic dyes), GQDs have substantial advantages, such as photostability, excellent solubility, low cytotoxicity and biocompatibility.
In this thesis, green fluorescent GQDs have been prepared via solvothermal method from graphite powder.Various analysis methods were utilized to characterization of the product. So, several experiments on GQDs in solution and in solid substrate at room temperature have been performed. The average size and height of the nanoparticles were about 44nm and 0.9 nm respectively. Also the results indicate that the synthesized GQDs have high solubility, excellent biocompatibility and favorable optical properties. Furthermore they can be used directly for cellular imaging without any surface processing or functionalization with high concentration
Keywords:
Graphene ; Cancer ; Cancer Diagnosis ; Imaging ; Graphene Quantum Dots (GQDs) ; Fluorophore