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Preparation of Hemodialysis Membrane on the Basis of Polysulfone

Sajjadi, Morteza | 2015

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 46773 (06)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Moosavi, Ali; Abd Khodaei, Mohammad Jafar
  7. Abstract:
  8. In Hemodialysis, membrane dialyser and commonly hollow fibers are used to treat patients who suffer from end stage renal failure. When blood flows into membrane, it loses uremic toxins such as urea and creatinine. On the other hand, some of the vital proteins of blood pass through the membrane or they are adsorbed on the membrane surface. The more hydrophilicity of the membrane, the less adsorption of proteins is. In this study, to achieve high hydrophilicity and low adsorption of proteins on the polysulfone membrane surface, the presence of hydrophilic nano-particles SBA-15 in membrane composition is investigated. The nano-particles with mass percentages 0.25%, 0.5 % and 1 % to one mass of the polymer, are added to dope solution. The SEM images of modified membranes show that the structure of the membrane is improving up to 0.5% addition of nano-particles. In 0.5%, the sponge-like structure of pure membrane (PSF) is converted to figure-like. Also, the amount of porosity increses and the mean pore size of the membrane decreases. In contrary, pure water flux shows decreasing trend with addition of the nano-particles. The most removal of urea and creatinine is observed by using the membranes with 0.5% nano-prticle. Indeed, in this level of added nanoparticles, the efficiency of the modified membrane is approximately equivalent to the pure memberane; Moreover, untifouling properties of membranes with Protein (BSA) has improved
  9. Keywords:
  10. Hemodialysis ; Polysulphone ; Proteins ; Nanoparticles ; Hollow Fiber Membrane ; Kidney Diseases

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