Simulation of the Urinary Concentration Mechanism

Mahdavi Salimi, Sharareh | 2015

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 46869 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abd Khodaei, Mohammad Jafar; Farhadi, Fathollah
  7. Abstract:
  8. The kidneys serve essential regulatory roles in the body which remove excess organic molecules from the blood and the removal of waste products of metabolism. They are essential in the urinary system. Urinary concentration mechanism has long been interested for mathematicians and physiologists to elucidate the obscurities within the process. In this study, a novel three-dimensional approach is used for simulating urine concentrating mechanism in rat renal medulla. The model equations are based on three spatial dimensions mass and momentum transports. Exact 3D geometry has been designed by using COMSOL Multiphysics software and results have been compared with the latest available data. In this study, inner and outer renal medulla has been simulated simultaneously. One of the most distinct privileges of this study is concentration and osmolality section view results. The results of this study have the least deviation with available data in comparison with previous works. Osmolality of short descending nephrons at the end of the outer medulla has been obtained to be 520-530mOsmol/kgH2O and osmolality of long descending nephrons at this section has been 800mOsmol/kgH2O. Meanwhile, osmolality of long ascending nephrons has been less than the osmolality of blood plasma (290mOsmol/kgH2O). Osmolality at the end of the collecting duct in the inner medulla has been obtained to be 1198 mOsmol/kgH2O which just has 48/1% relative error in comparison with experimental data
  9. Keywords:
  10. Simulation ; Kidney ; Urine Concentrating Mechanism ; Outer Medulla ; Inner Medulla

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