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Use of Suitable Methods in Synthesis of Spiropyrrolididne Oxindole, Polysubstituted Thiophene, Thiopyrano Benzosultone and Pyrimidines by Cycloaddition Reactions

Khodabakhshi, Mohammad Reza | 2015

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 47259 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Matloubi Moghaddam, Firouz
  7. Abstract:
  8. We have reported a new and efficient synthesis of a broad spectrum of heterotetracyclic thiopyranoindole via knovenagel hetero diels alder reaction.Fused pyrimidines have attracted considerable attention in synthetic organic chemistry because of their wide range of biological activities pharmaceutical and therapeutic properties, and antibacterial, antiviral, antitumor, and anti-inflammatory activities. We have reported a new efficient method for synthesis of pyrimidines fused to coumarine, uracile, cyclohexane and triamino pyrimidine structures. The major benefits of the current study are high yields, short reaction times, mild reaction conditions and available materials..We have also developed One-Pot, three-component regiospecific synthesis of dispiropyrrolidine containing thiophenone ring system via 1,3-Dipolar Cycloaddition Reaction of azomethine ylide. We have reported a new and efficient one-pot synthesis of polysubstituted thiophene from various β-keto dithioester and α-halocarbonyl and isocyande compounds. The present procedure has advantage that, not only good functional group tolerance and high yields, but also the reaction can be preformed under green and mild conditions
  9. Keywords:
  10. Hetero Diels-Alder ; Thiophene ; Azomethine Ylide ; Isocyanide ; Pyrimidines ; Cycloaddition Reaction ; Knoevenagel Condensation ; Spirooxindole ; Thiopyranoindole

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