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A sustainable approach to the Ugi reaction in deep eutectic solvent

Azizi, N ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1016/j.crci.2013.05.013
  3. Publisher: 2013
  4. Abstract:
  5. The Ugi reaction goes fast with high yields in a recyclable and biodegradable low-melting mixture of choline chloride and urea (DES) as a novel and efficient reaction medium. The DES is applicable to a wide range of aldehydes, amines, isocyanides, and acids in good to excellent isolated yields (60-92%) and short reaction times (2-5 h) and can be reused four times without any loss of activity
  6. Keywords:
  7. Choline chloride ; Deep eutectic solvent ; Green chemistry ; Ugi reaction ; Urea
  8. Source: Comptes Rendus Chimie ; Volume 16, Issue 12 , 2013 , Pages 1098-1102 ; 16310748 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S163107481300163X