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Simulation of Intravitreal Drug Delivery Systems

Haghjou, Nahid | 2015

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 47517 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abd Khodaei, Mohammad Jafar
  7. Abstract:
  8. As diseases of eye’s posterior segment has got widespread outbreak in the world, the selection of treatment is very important. Until now, intravitreal injecton has been the most common way of drug delivery to the posterior segment. Although this method is effective, halflife of some drugs in the vitreous cavity, especially those with low molecular weight, is just about some hours. Therefore, it is necessary to repeat injection in order to maintain drug concentration level of the posterior segment in the desired level. Intravitreal injection is invasive and may cause severe adverse effects such as vitreous hemorrhage, retinal detachment, endophthalmitis and cataract. In order to decrease the occurrence of complications associated with intravitreal injections, researchers are investigating new modes of drug delivery and improved long-acting formulations. The aim of this research is to simulate different intravitreal drug delivery systems such as direct injection of drug in the form of solution whether in water phase or oil phase, suspension as well as solid non-biodegradable implants. The simulation results show that oily solutions of drugs have more intravitreal residence time with respect to water solution of drugs having the same physicochemical properties. Furthermore the simulation results confirm that suspension form of drugs and implants have much more intravitreal bioavaiability and are more suitable for long term drug delivery. Simulation is done using FLUENT V. 6.3.26 software which is based on finite volume method. Furthermore, different factors such as physiological conditions of the eye and drug physicochemical properties which influence on drug distribution and elimination pathway have been investigated
  9. Keywords:
  10. Simulation ; Computational Fluid Dynamics (CFD) ; Fluent Software ; Pharmacokinetic ; Eye Posterior Segment ; Intravitreal Drug Delivery System

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