Loading...

Whole cell mechanical property characterization based on mechanical properties of its cytoplasm and bio membrane

Abbasi, A. A ; Sharif University of Technology | 2012

925 Viewed
  1. Type of Document: Article
  2. DOI: 10.1115/IMECE2012-85027
  3. Publisher: 2012
  4. Abstract:
  5. Analysis and investigation of the relation between different parts of biological cells such as biomembrane, cytoplasm and nucleus can help to better understand their behaviors and material properties. In this paper, first, the whole elastic properties of mouse oocyte and embryo cells have been computed by inverse finite element and Levenberg-Marquardt optimization algorithm and second, using the derived mechanical properties and the mechanical properties of its bio membrane from the literature, the mechanical properties of its cytoplasm has been characterized. It has been assumed that the cell behavior is as continues, isotropic, nonlinear and homogenous material for modeling. Matching the experimental forces with the forces from the finite element (FE) simulation by the Levenberg-Marquardt optimization algorithm, gives the nonlinear hyperelastic model parameters for the whole cell. Experimental data of mouse oocyte and embryo cells captured from the literatures
  6. Keywords:
  7. Biological cells ; Cell behaviors ; Elastic properties ; Finite element simulations ; Hyperelastic models ; Inverse finite elements ; Levenberg-Marquardt optimization ; Property characterizations ; Algorithms ; Cells ; Computer simulation ; Cytology ; Finite element method ; Mammals ; Mechanical engineering ; Mechanical properties ; Biomechanics
  8. Source: ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), 9 November 2012 through 15 November 2012 ; Volume 2 , November , 2012 , Pages 545-551 ; 9780791845189 (ISBN)
  9. URL: http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleid=1750427