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A lupane triterpenoid and other constituents of Salvia eremophila

Farimani, M. M ; Sharif University of Technology | 2012

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  1. Type of Document: Article
  2. DOI: 10.1080/14786419.2011.635345
  3. Publisher: 2012
  4. Abstract:
  5. Phytochemical investigation of the aerial parts of Salvia eremophila led to the isolation of a lupane triterpenoid, 3β, 20-dihydroxylupane-28-oic acid (1), together with eight other compounds, comprising three diterpene, two triterpene, two flavonoids and a steroidal glucoside. Their structures were elucidated by interpretation of their one-dimensional and two-dimensional NMR spectra and completed by the analysis of the HRESIMS data. Compounds 1, 2-4 and 8 were evaluated for their cytotoxicities against five human tumour cell lines. Compounds 1 and 3 hold a good potential for use in future studies due to their anti-cancer properties
  6. Keywords:
  7. Cytotoxicity ; Diterpenoids ; Triterpenoids ; 3beta,20 dihydroxylupane 28 oic acid ; Diterpene ; Flavonoid ; Steroid ; Triterpene derivative ; Triterpenoid ; Unclassified drug ; Cancer cell culture ; Carbon nuclear magnetic resonance ; Drug cytotoxicity ; Drug isolation ; Drug screening ; Human ; Human cell ; Medicinal plant ; Nonhuman ; Phytochemistry ; Proton nuclear magnetic resonance ; Salvia eremophila ; Structure activity relation ; Antineoplastic Agents, Phytogenic ; Cell Line, Tumor ; Diterpenes ; Drug Screening Assays, Antitumor ; Flavonoids ; Hep G2 Cells ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Plant Components, Aerial ; Salvia ; Terpenes ; Triterpenes
  8. Source: Natural Product Research ; Volume 26, Issue 21 , 2012 , Pages 2045-2049 ; 14786419 (ISSN)
  9. URL: http://www.tandfonline.com/doi/full/10.1080/14786419.2011.635345#.VoIM9i6Hi-E