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Biomedical applications of cyclodextrin-polymers

Adeli, M ; Sharif University of Technology | 2012

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  1. Type of Document: Article
  2. Publisher: Nova Science Publishers, Inc , 2012
  3. Abstract:
  4. This chapter explains biomedical applications of cyclodextrin-polymers. Cyclodextrins (CDs) are a class of natural cyclic oligosaccharides with 6, 7, or 8 D-(+)-glucose units linked by α-1, 4-linkages. The geometry of CDs gives a hydrophobic internal cavity that various organic, inorganic and biological molecules can be fitted in it. Many hydroxyl groups are situated on the outer parts of the rings, which make some of CDs water-soluble. These unique physicochemical properties of CDs make them promising materials to design polymeric systems. In the present chapter, first, the effect of CDs on solubility, stability and bioavailability of drugs is described. Second, polymeric systems based on CDs, such as polyrotaxanes, micelles, physical hydrogels and chemical hydrogels are discussed. Finally, based on a summary of the recent papers potential applications of these systems in drug and gene delivery are discussed
  5. Keywords:
  7. Source: Hybrid Nanostructures in Cancer Therapy ; Volume 47, Issue 3 , Aug , 2012 , Pages 25-46 ; 9781621005179 (ISBN)
  8. URL: https://www.novapublishers.com/catalog/product_info.php?products_id=29121&osCsid