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- Type of Document: Article
- Publisher: Nova Science Publishers, Inc , 2012
- Abstract:
- Dendrimers are generally described as macromolecules that are characterized by their extensively branched three dimensional structures which provide a high degree of surface functionality and versatility. The unique properties associated with dendrimers such as uniform size, high degree of branching, water solubility, multivalency, well-defined molecular weight and available internal cavities makes them attractive to use in nanomedicine.Nanomedicine is explained as the application of nanotechnology to health. It exploits the improved and frequently novel physical, chemical, and biological properties of materials at the nanometric scale. Nanomedicine has potential impact on the prevention, early and reliable diagnosis and therapy of diseases. Nanomedicine encompasses the three interrelated subjects of:• nanodiagnostics including imaging• targeted drug delivery and controlled release• regenerative medicineCancer is one of the most intricate diseases including a multitude of molecular and cellular processes, arising as the final result of a gradual accumulation of genetic changes caused by different factors in specific cells. A useful drug carrier system should have a high drug loading and suitable release properties together with long shelf-life and low toxicity [1].Dendrimers are ideal delivery systems for unambiguous study of the effects of polymer properties including size, charge, and composition on the biologically relevant properties such as lipid bilayer interactions, cytotoxicity, internalization, blood plasma-retention time, biodistribution, and filtration [2]
- Keywords:
- Source: Hybrid Nanostructures in Cancer Therapy ; 2012 , Pages 47-68 ; 9781621005179 (ISBN)
- URL: https://www.novapublishers.com/catalog/product_info.php?products_id=29121&osCsid