Facile, Efficient and Low Cost Synthesis of N-(1H-imidazoline-2-yl)-1H-Benzimidazol-2-Amine and its Derivatives

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| 2015

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 47829 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Mahmoodi Hashemi, Mohammed
Abstract:
Benzimidazoles are a bioactive family of chemicals which had been subject of many studies because of their valuable properties, and has a long history of production in chemical industries. Investigation on their properties and reactions with goal of achieving to new derivatives have drawn attention of many research teams. Recently, 2- Imidazolineaminobenzimidazole had been synthesized by microwave-assisted reaction of 2-Aminobenzimidazole with 2-Methylsulfanylimidazoline hydrogen iodide. But because of difficulties aroused by use of microwave system and expensive chemicals, we decided to utilized reaction procedures which could be facile, inexpensive with capability of high reaction scales. So 2-Guanidinobenzimidazole which has very interesting ability of production of fused-ring heterocycles had been synthesized as precursor to 2- Imidazolineaminobenzimidazole, which had been used in a simple reaction procedure to yield racemic four ring fused-ring heterocyclic system, which was synthesized for the first time. Reaction in present thesis had been chosen to have simple chemistry and be capable of utilizing them in larger scale reaction procedure
Keywords:
Heterocylic Compounds ; 2-Aminobenzimidazole ; 2-Guanidinobenzimidazole ; 2-Imidazolineaminobenzimidazole

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