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High-capacity hierarchically imprinted polymer beads for protein recognition and capture

Nematollahzadeh, A ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1002/anie.201004774
  3. Publisher: 2011
  4. Abstract:
  5. Leaving an imprint: Hierarchical protein imprinting starting from wide-pore silica modified with a submonolayer of adsorbed protein (IgG or HSA) leads to an inverse polymeric replica of the silica template that features highly accessible protein-complementary binding sites (see picture). The resulting poly(acrylamide) beads (PIgG or PHSA) feature high binding capacities and can be used to selectively capture the proteins HSA and IgG from blood serum
  6. Keywords:
  7. Materials science ; Protein imprinting ; Binding capacities ; Blood serum ; High-capacity ; Human serum albumins ; Immunoglobulin G ; Imprinted polymers ; Protein recognition ; Silica templates ; Submonolayer ; Wide-pore silica ; Amides ; Binding sites ; Biochemistry ; Body fluids ; Silica ; Proteins ; Acrylic acid resin ; Polyacrylamide ; Chemistry ; Molecular imprinting ; Acrylic Resins ; Humans ; Molecular Imprinting ; Polymers ; Serum Albumin
  8. Source: Angewandte Chemie - International Edition ; Volume 50, Issue 2 , December , 2011 , Pages 495-498 ; 14337851 (ISSN)
  9. URL: http://onlinelibrary.wiley.com/doi/10.1002/anie.201004774/abstract;jsessionid=8706612D0E52C22D65F15F76EA58D130.f03t03