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Designing a Mathematical Model for Optimizing Organ Transplant Network

Poursaeed, Alireza | 2015

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 48151 (01)
  4. University: Sharif University of Technology
  5. Department: Industrial Engineering
  6. Advisor(s): Najafi, Mehdi
  7. Abstract:
  8. Presently, numerous patients die each day while they are awaiting life-saving organ transplant. Despite advances in medicine and technology, and increased awareness of organ donation and transplantation, the gap between supply and demand continues to widen. Therefore, appropriate utilization of donated organs under organ allocation process is vital, and can save several patients’ life. Due to this cause, this study presents a mixed integer multi-period mathematical model to optimize allocation system in an organ transplantation network. The considered network includes donors, hospitals, procurement centers, transplant centers, and patients. The proposed model strives to minimize the overall transplantation time consisting the times are necessary for removing the organs, transferring between different centers, transplant surgery, and patients’ waiting time. In addition to minimization of patients’ waiting time, the proposed model aims to minimize the number of patients dying in the transplantation queue. Furthermore, due to more priority of emergent patients, this model uses a priority queuing model to utilize the prioritized allocation of the available organs. Finally, regarding to the highly nonlinearity of the proposed model, a heuristic method is suggested to solve it in larger scale cases
  9. Keywords:
  10. Mathematical Programming ; Optimum Allocation ; Queuing Theory ; Prioritization ; Patient Waiting Time ; Organ Transplant Network

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