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A convenient synthesis of 3-formyl-2-thioacetamide-indole derivatives via the one-pot reaction of indolin-2-thiones, isocyanides and chloroacetylchloride

Kiamehr, M ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.tetlet.2015.11.044
  3. Abstract:
  4. An efficient method has been developed to construct 3-formyl-2-thioacetamide-indoles via a one-pot, two-step procedure involving condensation of isocyanides with indolin-2-thiones to give a 3-aminomethylene-indolin-2-thione intermediate, followed by regioselective reaction with chloroacetylchloride and subsequent hydrolysis
  5. Keywords:
  6. Indole derivatives ; Indolin-2-thiones ; Isocyanide ; Methylene-indolin-2-thiones ; Hydrolysis ; One pot synthesis ; Synthesis
  7. Source: Tetrahedron Letters ; Volume 56, Issue 52 , 2015 , Pages 7190-7192 ; 00404039 (ISSN)
  8. URL: http://www.sciencedirect.com/science/article/pii/S004040391530352X