Optimal-Robust Control of Drug Delivery in Cancer Chemotherapy

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Hosseini, Fatemeh | 2015

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 48413 (08)
University: Sharif University of Technology
Department: Mechanical Engineering
Advisor(s): Moradi, Hamed
Abstract:
Chemotherapy is a proven and effective systematic approach to treat various types of cancers. Despite its advantages, chemotherapy would kill healthy as well as cancer cells. To overcome this problem, different controlling strategies are implemented. This study aims to provide a medicine drug delivery schedule for chemotherapy (by designing a proper controlling system) based on the verifiable mathematical models. First, the dynamic model is analysed and stability points are reviewed. The selected model has five state variables and two inputs. In this study, the focus is on dynamic model analysis and obtaining an effective and appropriate treatment pattern by designing a proper controller. To develop a proper controlling system aimed at addressing the problem mentioned, three different algorithms, namely state-feedback; linear quadratic regulator; and µ-synthesis are implemented and studied under both ideal conditions (no disturbances, noise or uncertainty) and real-time (considering restrictions) and compared accordingly
Keywords:
Robust Control ; Optimal Control ; State Feedback ; Disturbance Theory ; Uncertainty ; Cancer Chemotherapy

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