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Rapid microwave-assisted synthesis of PVP-coated ultrasmall gadolinium oxide nanoparticles for magnetic resonance imaging

Vahdatkhah, P ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1016/j.chemphys.2015.03.007
  3. Publisher: Elsevier , 2015
  4. Abstract:
  5. Synthesis of polyvinyl pyrrolidone (PVP) coated ultrasmall Gd2O3 nanoparticles (NPs) with enhanced T1-weighted signal intensity and r2/r1 ratio close to unity is performed by a microwave-assisted polyol process. PVP coated Gd2O3NPs with spherical shape and uniform size of 2.5 ± 0.5 nm have been synthesized below 5 min and structure and morphology confirmed by HRTEM, XRD and FTIR. The longitudinal (r1) and transversal relaxation (r2) of Gd2O3NPs is measured by a 3 T MRI scanner. The results showed considerable increasing of relaxivity for Gd2O3NPs in comparison to gadolinium chelates which are commonly used for clinical magnetic resonance imaging. In addition, a mechanism for Gd2O3NPs formation and in situ surface modification of PVP-grafted Gd2O3NPs is proposed
  6. Keywords:
  7. Contrast agent ; Gadolinium oxide ; Microwave ; MRI imaging ; Nanoparticle ; Polyol process
  8. Source: Chemical Physics ; Volume 453-454 , May , 2015 , Pages 35-41 ; 03010104 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0301010415000774