Design and Simulation of a Passive Microfluidic Device for Particle Separation

Vatankhah, Parham | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 48526 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Shamloo, Amir
  7. Abstract:
  8. Nowadays, separation and filtration of particles has many industrial applications in biology and medicine. In this thesis, passive microfluidics are designed and simulated which are able to separate and filter particles. Although particles aer generally expected to follow laminar flow streamlines in the absence of external forces, inertial forxes van cause particles to migrate across mictochannels in an accurate and predictable manner. The effect of these forces is invedtigated, and by using previous research, a model is developed to predict these forces. First design is a microchannel with Archimedean spiral which utilizes both inertial forces and Dean flow to separate particles in the range of 5 to 20 micrometers. In inertial microfluidics, particles sizes are dependent to the size of microchannels cross section. Thus, in order to separate smaller micron sized particles, the cross section of the microchannel should be reduced. However, with reducing the size of the cross section, formation of Dean flow needs higher speed which are not feasible in microflluidics. In order to respond this need, a straight microchannel is modeled which is able to filter particles up to a few hundred nanometers. The simple planar nature of the devixes should permit intefration with the existing lab on a chip (LOC) systems
  9. Keywords:
  10. Separation ; Microfluidic Devices ; Filtration ; Inertial Forces ; Particles Separation ; Passive Microfluidic ; Dean Flow

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