Manufacturing of Polymeric Biodegradable Nanocomposites for Musculoskeletal Fixation Devices

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Amiri Moghaddam, Sadegh | 2016

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 48678 (06)
University: Sharif University of Technology
Department: Chemical and Petroleum Engineering
Advisor(s): Ramezani Saadatabadi, Ahmad; Emami Meibodi, Mohammad Kazem
Abstract:
Fixation devices and implants are the most applied devices in orthopedic operation and dentistry. Interference screw is one of these devices that is made by biodegradable nanocomposite polymeric materials in this project. The purpose of this project is designing interference screw, applicable to body, and doing related tests since in vivo tests. For this purpose, hand injection molding, was designed to prepare screws in laboratory scale, first. For making samples, poly(D,L) lacticacid, nano hydroxyapatite as reinforce and polyethylene glycol as plasticizer were used. These samples were made by combination of solvent casting and melt processing methods. Adding nano hydroxyapatite and polyethylene glycol together lead to improve tensile and percent elongation of sampels. After doing different tests like tensile, rheology, differential sccaning calorimetry, biodegradability and biocompatibility, the optimized sample was chosen
Keywords:
Nanocomposite ; Biodegradable Nanocomposites ; Musculoskeletal System ; Polylactic Acid ; Hydroxyapatite Naoparticles ; Interference Screw

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