Mechanical Model in Cell and Nucleus Deformation

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Heydari, Tiam | 2016

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 48789 (04)
University: Sharif University of Technology
Department: Physics
Advisor(s): Ejtehadi, Mohammad Reza
Abstract:
Now a days, the ability of measuring the mechanical properties of the living cells in in experiments has been increased. Experiments shows that the stem cells could alter their faith in different mechanical situations, but an integrated model about this phenomenon in literature has not been introduced yet. In this research thesis s minimal cell model (MMC) is developed to capture the behavior of the cells on substrates with varying mechanical properties and morphologies, MMC consists of large scale models for outer membrane of the cell and nuclear envelope, cytoplasmic area, chromatin fibers and Extra cellular matrix. Each component of the MMC will be placed in an integrated software to simulate the cell behavior and the response of the MMC to different situations is tested. For example the cell become elongated in grooved substrate in groove direction and this elongation increases with increasing of the grooves depth
Keywords:
Viscoelastic Model ; Mechanical Properties ; Molecular Dynamics ; Cell Mechanics ; Cell Rheology ; Chromatin Fibers