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Loading of Doxorubicin on Stimuli-Responsive Nanocarriers and Investigation of its Release

Yaghoubi, Mahshid | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 48979 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Pourjavadi, Ali
  7. Abstract:
  8. Drug targeting to specific organs and tissues has become one of the critical endeavors of the new century. Magnetic nanoparticles have gained a lot of attention in biomedical and industrial application. Doxorubicin is an effective anti-cancer drug in the treatment of many types of cancers. The aim of this study is to load doxorubicin on stimuli-responsive nanocarriers. These nanocarriers are prepared from magnetic nanoparticles. Then these magnetic nanparticles are coated by copolymer of poly(glycidyl methacrylate) then reacted with hydrazine and hydrazide functional group is formed that can chemically be bonded with the anticancer drug doxorubicin via a hydrazone bond formation. This interaction is sensitive to changes of pH and by reducing the pH, drug is separated from the surface of nanocarrier and released into cancerous cells. The analysis test like FT-IR, DLS, TEM demonstarated the synthesis of nanocarrier and their nanosize. The in vitro release of drug was examained by UV-Vis spectrometers. Using of the magnetic nanoparticles in this kind of nanocarriers, in addition to magnetic guiding toward tumors, improves magnetic resonance imaging (MRI) and by this approach aggregation of nanocarrier in organs can be investigated
  9. Keywords:
  10. Nanocarrier ; Magnetic Iron Oxide Nonoparticle ; Doxorubicin ; Drug Delivery ; PH-Sensitive Polymer ; Benzimidazol ; Anticancer Drugs ; Stimuli-Responsive

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