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Simulation of a PEM (Positron Emission Mammography) System by GATE

Reshtebar, Niloofar | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49218 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Sohrabpour, Mostafa; Setayeshi, Saeed
  7. Abstract:
  8. Breast cancer is the second leading cause of cancer death among women. Mammography is considered the “gold standard” in the evaluation of the breast lesions from an imaging perspective. But this modality has limitations. Completed studies are used to overcome these limitations. The Positron Emission Mammography (PEM) is the one of these complementary methods. PEM imaging is a molecular imaging modality for the diagnosis of breast cancer. In this thesis, a commercial PEM system as Naviscan PEM has been simulated using the GATE program. This system consists of two parallel planes of detectors, each detector consists of 12 blocks with 6 × 2 array and each block consists of 169 crystals with 13 × 13 array. In order to evaluate system performance, two parameters were evaluated sensitivity and scatter fraction. Performance of system were evaluated by changing the factors affecting these parameters. The factors studied in this thesis are scintillator, block array in detector, separation distance between detectors, phantom radius and the dose of injection. The results showed that the sensitivity of GSO crystal is almost 2 times YAP crystal and 4 times LYSO crystal. But scatter fraction in the GSO crystal 5/1% higher than the LYSO crystal. Scatter fraction of YAP crystal is about 6% higher than of LYSO crystal and 5% of GSO crystal. Also, by increasing the number of columns of blocks, sensitivity increases. In all three types of crystal, with increase the number of columns of blocks of 6 × 1 array to 6 × 2 array, sensitivity increases about 5.4 times the system. Evaluate and quantify these changes play an important role in designing the new PEM systems
  9. Keywords:
  10. Breast Cancer ; Simulation ; Positron Emission Tomography (PET) ; Mammography ; Geant4 Application for Tomographic (GATE)Emission ; Positron Emission Mammography

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