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DNA binding and recognition of a CC mismatch in a DNA duplex by water-soluble peptidocalix[4]arenes: synthesis and applications

Alavijeh, N. S ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1021/acs.orglett.6b01995
  3. Publisher: American Chemical Society
  4. Abstract:
  5. Water-soluble peptidocalix[4]arenes were synthesized by the introduction of arginine-rich narrow groove-binding residues at lower rims through solid-phase synthesis. The study of binding of these water-soluble bidentate ligands to well-matched and mismatched DNA duplexes by fluorescent titrations, ethidium bromide (EB) displacement assays, DNA-melting experiments, and circular dichroism (CD) analysis revealed a sequence-dependent groove-binding mechanism
  6. Keywords:
  8. Source: Organic Letters ; Volume 18, Issue 19 , 2016 , Pages 4766-4769 ; 15237060 (ISSN)
  9. URL: http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01995