Surface Modification and Stabilization of TiO2 Nanoparticles for Sonodynamic Therapy

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Younesi, Hamid | 2017

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 49675 (57)
University: Sharif University of Technology, International Campus, Kish Island
Department: Science and Engineering
Advisor(s): Maddah Hosseini, Hamid Reza
Abstract:
Sonodynamic therapy has been developed over the last century, now it has become more widely used as a medical tool for the treatment of various diseases such as cancer. This technique involves delivery of sonosensitizing drugs, irradiation of ultrasound waves and motivation of drugs. In this thesis surface modification process with polymer and biocompatible surfactant on TiO2 nanoparticles has been done due to stabilization of TiO2 nanoparticles in neutral pH which is similar to inside-body situation. In the last step, for cancer therapy, doxorubicin as a cancer drug was loaded on TiO2 which was surface modified by PVA. The results revealed the best ratio of (PVA: TiO2), (SDS: TiO2), (SDS: PVA: TiO2), (PEG: SDS: TiO2) in neutral pH which is similar to inside-body situation
Keywords:
Doxorubicin ; Sodium Dodecyl Sulfate ; Poly Vinyl Alcohol ; Biocompatibility ; Colloidal Stability ; Cancer Treatment ; Sonodynamic Therapy

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