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Design of Smart Magnetic Micellar Nanocarrier Based on Modified Polycaprolactone for Targeting Delivery of Paclitaxel as Anticancer Drug

Dastanpour, Lida | 2017

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49826 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Pourjavadi, Ali
  7. Abstract:
  8. Today, current methods are used for treatment of cancers. Patient experiences a period of hard treatment during destruction of both healthy and diseased cells. Researchers are following stimulus- response drug delivery systems that they control time and position of drug release. Meanwhile, micellar nanoparticles are important, because it can transport the hydrophobic anticancer drugs from body's physiological barriers. On the other hand, tumour tissue has low pH and high temperature as compared to health tissue. Therefore, using pH and thermosensitive polymer coating could be effective in triggered drug release. In the first study, micellar systems were synthesized which were responsive to variable pHs. Then PEG-PCL-PEG copolymer was coated on Fe3O4 @ oleic acid nanoparticle. Finally, Taxol was loaded on micellar nanoparticles, and then drug release profile was investigated at pH=5.5(tumor tissue) and pH=7.4(healthy tissue) at 37˚C. In this regard, another micellar system was designed with thermosensitive ability. In the second study, PNIPAM-PCL-PNIPAM triblock copolymer was synthesized and coated on Fe3O4@oleic acid nanoparticles. In vitro drug release profile was studied in different temperature conditions. These nanocarriers are characterized by various techniques including SEM, TGA, UV-Vis, DLS, FT-IR, 1H-NMR, AFM and MTT cell toxicity assay
  9. Keywords:
  10. Anticancer Drugs ; Amphiphilic Nanoparticle ; Pacli Taxel (PTX) ; Targeted Druy Delivery ; PH-triggered Release ; Cancer Treatment ; Micelle-Like Nanostructure ; Polycaprolactone Composite ; Amphiphilic Copolymer

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