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Interaction of Mg2+, Ca2+, Zn2+ and Cu+ with cytosine nucleosides: Influence of metal on sugar puckering and stability of N-Glycosidic bond, a DFT study

AliakbarTehrani, Z ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. DOI: 10.1016/j.theochem.2009.07.026
  3. Publisher: 2009
  4. Abstract:
  5. The coordination geometries, electronic features, absolute metal ion affinities, geometrical multiplicity and binding strength for the complexes formed by Mg2+, Ca2+, Zn2+ and Cu+ with cytidine and deoxycytidine have been determined theoretically employing the hybrid B3LYP exchange-correlation functional and using 6-311++G(d,p) orbital basis sets. Our study shows that the most stable coordination modes of cytosine nucleosides with these cations are rather similar. In the isolated state, the most stable form corresponds to a tridentate complex in which the cation interacts with three oxygen atoms: one from the carbonyl oxygen of cytosine moiety and two from the sugar unit (i.e., O5′ and O4′). The influences of metal cationization on the strength of the N-glycosidic bond, the values of the phase angle of pseudorotation P in the sugar unit and sugar ring conformation have been studied. In all cases, the N1{single bond}C1′ bond distance changes upon introducing positive charge in the nucleosides. © 2009 Elsevier B.V. All rights reserved
  6. Keywords:
  7. Metal ion binding sites ; DFT study ; N-glycosidic bond ; Sugar puckering mode
  8. Source: Journal of Molecular Structure: THEOCHEM ; Volume 913, Issue 1-3 , 2009 , Pages 117-125 ; 01661280 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0166128009004837